Mark Fillmore

mtfill2's picture
Graduate Training: 
Ph.D. Univ. of Waterloo, 1993
Research: 

My research areas include behavioral pharmacology, substance abuse, and behavioral neuroscience. The general focus of my program concerns how acute doses of abused drugs alter behavioral and cognitive functioning in humans. The research combines measures of drug effects on cognitive processes with conventional assessments of abuse potential, based on subjective rewarding effects of the drug, and its ability to reinforce self-administration. The objective of these studies is to improve our understanding of how basic cognitive and behavioral mechanisms play a role in the development of substance abuse and drug addiction. Some of the general topics of study in my program include: the role impulsivity and ADHD as risk-factors for alcohol and other drug abuse, alcohol and disinhibition, alcohol and impaired driving, characteristics of DUI offenders, alcohol pharmacokinetics and alcohol tolerance.

The studies are primarily laboratory-based experiments and involve the administration of drugs to human participants under controlled conditions. Several cognitive and behavioral functions are evaluated, including: behavioral inhibition, memory, motor coordination, and information processing, and simulated driving performance. Drugs that are studied include: alcohol, cocaine, benzodiazepines, caffeine, and some current pharmacotherapies for drug abuse, such as naltrexone. The studies examine adults from various populations, including those with drug-abuse histories and those with no history of drug abuse.

My research program is funded by NIH grants from the National Institute of Alcohol Abuse and Alcoholism. The research is ideally suited for graduate training of students with a broad range of interests (neuroscience, clinical, cognition, etc.). Applicants to our graduate program with undergraduate research backgrounds in animal research and human cognition/learning are especially suited for graduate training in my lab. To see some brief video clips of our research techniques, click on the User Links on this page. 

PubMed Publications*: 
  • Van Dyke, N ;Fillmore, MT "Acute effects of alcohol on inhibitory control and simulated driving in DUI offenders." Journal of safety research 49, (2014): 5-11. Details. Full text
  • Roberts, W.;Fillmore, MT "Attentional Bias to Alcohol-Related Stimuli as an Indicator of Changes in Motivation to Drink." Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors (2014): Details.
  • Miller, MA ;Fillmore, MT "Protracted impairment of impulse control under an acute dose of alcohol: a time-course analysis." Addictive behaviors 39, 11 (2014): 1589-96. Details. Full text
  • Weafer, J.;Fillmore, MT "Alcohol-Related Cues Potentiate Alcohol Impairment of Behavioral Control in Drinkers." Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors (2014): Details.
  • Sklar, AL ;Boissoneault, J ;Fillmore, MT ;Nixon, SJ "Interactions between age and moderate alcohol effects on simulated driving performance." Psychopharmacology 231, 3 (2014): 557-66. Details. Full text
  • Weafer, J.;Fillmore, MT "Acute alcohol effects on attentional bias in heavy and moderate drinkers." Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors 27, 1 (2013): 32-41. Details. Full text
  • Miller, MA ;Fillmore, MT "Can the use of multiple stop signals reduce the disinhibiting effects of alcohol?" Alcoholism, clinical and experimental research 37, 11 (2013): 1947-53. Details. Full text
  • Marczinski, CA ;Fillmore, MT ;Henges, AL ;Ramsey, MA ;Young, CR "Mixing an energy drink with an alcoholic beverage increases motivation for more alcohol in college students." Alcoholism, clinical and experimental research 37, 2 (2013): 276-83. Details. Full text
  • Roberts, W.;Milich, R.;Fillmore, MT "The Effects of Preresponse Cues on Inhibitory Control and Response Time in Adults With ADHD." Journal of attention disorders (2013): Details. Full text
  • Marczinski, CA ;Fillmore, MT "Letter to the editor in response to "The alcohol mixed with energy drinks debate: masking the facts!"." Alcoholism, clinical and experimental research 37, 4 (2013): 706-8. Details. Full text
  • Weafer, J.;Fillmore, MT "Comparison of alcohol impairment of behavioral and attentional inhibition." Drug and alcohol dependence 126, 1-2 (2012): 176-82. Details. Full text
  • Weafer, J.;Fillmore, MT "Alcohol-related stimuli reduce inhibitory control of behavior in drinkers." Psychopharmacology 222, 3 (2012): 489-98. Details. Full text
  • Fillmore, MT ;Weafer, J. "Acute tolerance to alcohol in at-risk binge drinkers." Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors 26, 4 (2012): 693-702. Details. Full text
  • Fillmore, MT "Commentary on McCarthy et al. (2012): understanding how alcohol affects decisions to drive while intoxicated-the need to deconstruct impulsivity." Addiction (Abingdon, England) 107, 12 (2012): 2115-6. Details. Full text
  • Weafer, J.;Fillmore, MT "Acute tolerance to alcohol impairment of behavioral and cognitive mechanisms related to driving: drinking and driving on the descending limb." Psychopharmacology 220, 4 (2012): 697-706. Details. Full text
  • Marczinski, CA ;Fillmore, MT ;Henges, AL ;Ramsey, MA ;Young, CR "Effects of energy drinks mixed with alcohol on information processing, motor coordination and subjective reports of intoxication." Experimental and clinical psychopharmacology 20, 2 (2012): 129-38. Details. Full text
  • Miller, MA ;Hays, LR ;Fillmore, MT "Lack of tolerance to the disinhibiting effects of alcohol in heavy drinkers." Psychopharmacology 224, 4 (2012): 511-8. Details. Full text
  • Weafer, J.;Milich, R.;Fillmore, MT "Behavioral components of impulsivity predict alcohol consumption in adults with ADHD and healthy controls." Drug and alcohol dependence 113, 2-3 (2011): 139-46. Details. Full text
  • Marczinski, CA ;Fillmore, MT ;Bardgett, ME ;Howard, MA "Effects of energy drinks mixed with alcohol on behavioral control: risks for college students consuming trendy cocktails." Alcoholism, clinical and experimental research 35, 7 (2011): 1282-92. Details. Full text
  • Miller, MA ;Fillmore, MT "Persistence of attentional bias toward alcohol-related stimuli in intoxicated social drinkers." Drug and alcohol dependence 117, 2-3 (2011): 184-9. Details. Full text
  • Harrison, EL ;Fillmore, MT "Alcohol and distraction interact to impair driving performance." Drug and alcohol dependence 117, 1 (2011): 31-7. Details. Full text
  • Weafer, J.;Miller, MA ;Fillmore, MT "Response conflict as an environmental determinant of gender differences in sensitivity to alcohol impairment." Current drug abuse reviews 3, 3 (2010): 147-55. Details. Full text
  • Miller, MA ;Fillmore, MT "The effect of image complexity on attentional bias towards alcohol-related images in adult drinkers." Addiction (Abingdon, England) 105, 5 (2010): 883-90. Details. Full text
  • Fillmore, MT "Processing bimodal stimulus information under alcohol: is there a risk to being redundant?" Experimental and clinical psychopharmacology 18, 5 (2010): 429-35. Details. Full text
  • Ostling, EW ;Fillmore, MT "Tolerance to the impairing effects of alcohol on the inhibition and activation of behavior." Psychopharmacology 212, 4 (2010): 465-73. Details. Full text
  • Adams, ZW ;Milich, R.;Fillmore, MT "Examining manual and visual response inhibition among ADHD subtypes." Journal of abnormal child psychology 38, 7 (2010): 971-83. Details. Full text
  • Weafer, J.;Fillmore, MT ;Milich, R. "Increased sensitivity to the disinhibiting effects of alcohol in adults with ADHD." Experimental and clinical psychopharmacology 17, 2 (2009): 113-21. Details. Full text
  • Marczinski, CA ;Fillmore, MT "Acute alcohol tolerance on subjective intoxication and simulated driving performance in binge drinkers." Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors 23, 2 (2009): 238-47. Details. Full text
  • Fillmore, MT ;Ostling, EW ;Martin, CA ;Kelly, TH "Acute effects of alcohol on inhibitory control and information processing in high and low sensation-seekers." Drug and alcohol dependence 100, 1-2 (2009): 91-9. Details. Full text
  • Weafer, J.;Fillmore, MT "Individual differences in acute alcohol impairment of inhibitory control predict ad libitum alcohol consumption." Psychopharmacology 201, 3 (2008): 315-24. Details. Full text
  • Fillmore, MT ;Blackburn, JS ;Harrison, EL "Acute disinhibiting effects of alcohol as a factor in risky driving behavior." Drug and alcohol dependence 95, 1-2 (2008): 97-106. Details. Full text
  • Weafer, J.;Camarillo, D.;Fillmore, MT ;Milich, R.;Marczinski, CA "Simulated driving performance of adults with ADHD: comparisons with alcohol intoxication." Experimental and clinical psychopharmacology 16, 3 (2008): 251-63. Details. Full text
  • Marczinski, CA ;Harrison, EL ;Fillmore, MT "Effects of alcohol on simulated driving and perceived driving impairment in binge drinkers." Alcoholism, clinical and experimental research 32, 7 (2008): 1329-37. Details. Full text
  • Harrison, EL ;Marczinski, CA ;Fillmore, MT "Driver training conditions affect sensitivity to the impairing effects of alcohol on a simulated driving test corrected ." Experimental and clinical psychopharmacology 15, 6 (2007): 588-98. Details. Full text
  • Marczinski, CA ;Combs, SW ;Fillmore, MT "Increased sensitivity to the disinhibiting effects of alcohol in binge drinkers." Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors 21, 3 (2007): 346-54. Details. Full text
  • Fillmore, MT ;Rush, CR ;Hays, L. "Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects." Addiction (Abingdon, England) 101, 9 (2006): 1323-32. Details. Full text
  • Marczinski, CA ;Fillmore, MT "Clubgoers and their trendy cocktails: implications of mixing caffeine into alcohol on information processing and subjective reports of intoxication." Experimental and clinical psychopharmacology 14, 4 (2006): 450-8. Details. Full text
  • Abroms, BD ;Gottlob, LR ;Fillmore, MT "Alcohol effects on inhibitory control of attention: distinguishing between intentional and automatic mechanisms." Psychopharmacology 188, 3 (2006): 324-34. Details. Full text
  • Fillmore, MT ;Rush, CR "Polydrug abusers display impaired discrimination-reversal learning in a model of behavioural control." Journal of psychopharmacology (Oxford, England) 20, 1 (2006): 24-32. Details. Full text
  • Marczinski, CA ;Fillmore, MT "Alcohol increases reliance on cues that signal acts of control." Experimental and clinical psychopharmacology 13, 1 (2005): 15-24. Details. Full text
  • Fillmore, MT ;Marczinski, CA ;Bowman, AM "Acute tolerance to alcohol effects on inhibitory and activational mechanisms of behavioral control." Journal of studies on alcohol 66, 5 (2005): 663-72. Details. Full text
  • Harrison, EL ;Fillmore, MT "Social drinkers underestimate the additive impairing effects of alcohol and visual degradation on behavioral functioning." Psychopharmacology 177, 4 (2005): 459-64. Details. Full text
  • Stoops, WW ;Lile, JA ;Fillmore, MT ;Glaser, PE ;Rush, CR "Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration." Psychopharmacology 182, 1 (2005): 186-93. Details. Full text
  • Fillmore, MT ;Rush, CR ;Abroms, BD "d-Amphetamine-induced enhancement of inhibitory mechanisms involved in visual search." Experimental and clinical psychopharmacology 13, 3 (2005): 200-8. Details. Full text
  • Marczinski, CA ;Fillmore, MT "Compensating for alcohol-induced impairment of control: effects on inhibition and activation of behavior." Psychopharmacology 181, 2 (2005): 337-46. Details. Full text
  • Marczinski, CA ;Abroms, BD ;Van Selst, M.;Fillmore, MT "Alcohol-induced impairment of behavioral control: differential effects on engaging vs. disengaging responses." Psychopharmacology 182, 3 (2005): 452-9. Details. Full text
  • Fillmore, MT ;Rush, CR ;Hays, L. "Cocaine improves inhibitory control in a human model of response conflict." Experimental and clinical psychopharmacology 13, 4 (2005): 327-35. Details. Full text
  • Fillmore, MT ;Kelly, TH ;Martin, CA "Effects of d-amphetamine in human models of information processing and inhibitory control." Drug and alcohol dependence 77, 2 (2005): 151-9. Details. Full text
  • Harrison, EL ;Fillmore, MT "Are bad drivers more impaired by alcohol? Sober driving precision predicts impairment from alcohol in a simulated driving task." Accident; analysis and prevention 37, 5 (2005): 882-9. Details. Full text
  • Harrison, EL ;Fillmore, MT "Transfer of learning to compensate for impairment by alcohol and visual degradation." Psychopharmacology 182, 4 (2005): 461-7. Details. Full text
  • Fillmore, MT ;Weafer, J. "Alcohol impairment of behavior in men and women." Addiction (Abingdon, England) 99, 10 (2004): 1237-46. Details. Full text
  • Abroms, BD ;Fillmore, MT "Alcohol-induced impairment of inhibitory mechanisms involved in visual search." Experimental and clinical psychopharmacology 12, 4 (2004): 243-50. Details. Full text
  • Fillmore, MT "Environmental dependence of behavioral control mechanisms: effects of alcohol and information processing demands." Experimental and clinical psychopharmacology 12, 3 (2004): 216-23. Details. Full text
  • Stoops, WW ;Glaser, PE ;Fillmore, MT ;Rush, CR "Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans." Journal of psychopharmacology (Oxford, England) 18, 4 (2004): 534-43. Details. Full text
  • Marczinski, CA ;Fillmore, MT "Dissociative antagonistic effects of caffeine on alcohol-induced impairment of behavioral control." Experimental and clinical psychopharmacology 11, 3 (2003): 228-36. Details. Full text
  • Stoops, WW ;Fillmore, MT ;Poonacha, MS ;Kingery, JE ;Rush, CR "Alcohol choice and amphetamine effects in light and moderate drinkers." Alcoholism, clinical and experimental research 27, 5 (2003): 804-11. Details. Full text
  • Fillmore, MT "Drug abuse as a problem of impaired control: current approaches and findings." Behavioral and cognitive neuroscience reviews 2, 3 (2003): 179-97. Details. Full text
  • Fillmore, MT "Alcohol tolerance in humans is enhanced by prior caffeine antagonism of alcohol-induced impairment." Experimental and clinical psychopharmacology 11, 1 (2003): 9-17. Details. Full text
  • Abroms, BD ;Fillmore, MT ;Marczinski, CA "Alcohol-induced impairment of behavioral control: effects on the alteration and suppression of prepotent responses." Journal of studies on alcohol 64, 5 (2003): 687-95. Details. Full text
  • Fillmore, MT ;Rush, CR ;Marczinski, CA "Effects of d-amphetamine on behavioral control in stimulant abusers: the role of prepotent response tendencies." Drug and alcohol dependence 71, 2 (2003): 143-52. Details. Full text
  • Marczinski, CA ;Fillmore, MT "Preresponse cues reduce the impairing effects of alcohol on the execution and suppression of responses." Experimental and clinical psychopharmacology 11, 1 (2003): 110-7. Details. Full text
  • Fillmore, MT "Reliability of a computerized assessment of psychomotor performance and its sensitivity to alcohol-induced impairment." Perceptual and motor skills 97, 1 (2003): 21-34. Details. Full text
  • Fillmore, MT ;Roach, EL ;Rice, JT "Does caffeine counteract alcohol-induced impairment? The ironic effects of expectancy." Journal of studies on alcohol 63, 6 (2002): 745-54. Details. Full text
  • Fillmore, MT ;Rush, CR ;Hays, L. "Acute effects of oral cocaine on inhibitory control of behavior in humans." Drug and alcohol dependence 67, 2 (2002): 157-67. Details. Full text
  • Fillmore, MT ;Blackburn, J. "Compensating for alcohol-induced impairment: alcohol expectancies and behavioral disinhibition." Journal of studies on alcohol 63, 2 (2002): 237-46. Details. Full text
  • Fillmore, MT ;Van Selst, M. "Constraints on information processing under alcohol in the context of response execution and response suppression." Experimental and clinical psychopharmacology 10, 4 (2002): 417-24. Details. Full text
  • Fillmore, MT ;Rush, CR "Impaired inhibitory control of behavior in chronic cocaine users." Drug and alcohol dependence 66, 3 (2002): 265-73. Details. Full text
  • Fillmore, MT "Cognitive preoccupation with alcohol and binge drinking in college students: alcohol-induced priming of the motivation to drink." Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors 15, 4 (2001): 325-32. Details. Full text
  • Fillmore, MT ;Kelly, TH ;Rush, CR ;Hays, L. "Retrograde facilitation of memory by triazolam: effects on automatic processes." Psychopharmacology 158, 3 (2001): 314-21. Details. Full text
  • Fillmore, MT ;Rush, CR ;Kelly, TH ;Hays, L. "Triazolam impairs inhibitory control of behavior in humans." Experimental and clinical psychopharmacology 9, 4 (2001): 363-71. Details. Full text
  • Fillmore, MT ;Vogel-Sprott, M. "Response inhibition under alcohol: effects of cognitive and motivational conflict." Journal of studies on alcohol 61, 2 (2000): 239-46. Details. Full text
  • Fillmore, MT ;Dixon, MJ ;Schweizer, TA "Alcohol affects processing of ignored stimuli in a negative priming paradigm." Journal of studies on alcohol 61, 4 (2000): 571-8. Details. Full text
  • Fillmore, MT ;Dixon, MJ ;Schweizer, TA "Differential effects of alcohol on responses to negatively and positively primed stimuli." Journal of studies on alcohol 61, 6 (2000): 872-80. Details. Full text
  • Fillmore, MT ;Vogel-Sprott, M. "An alcohol model of impaired inhibitory control and its treatment in humans." Experimental and clinical psychopharmacology 7, 1 (1999): 49-55. Details. Full text
  • Fillmore, MT ;Vogel-Sprott, M.;Gavrilescu, D. "Alcohol effects on intentional behavior: dissociating controlled and automatic influences." Experimental and clinical psychopharmacology 7, 4 (1999): 372-8. Details. Full text
  • Fillmore, MT ;Carscadden, JL ;Vogel-Sprott, M. "Alcohol, cognitive impairment and expectancies." Journal of studies on alcohol 59, 2 (1998): 174-9. Details. Full text
  • Fillmore, MT ;Vogel-Sprott, M. "Behavioral impairment under alcohol: cognitive and pharmacokinetic factors." Alcoholism, clinical and experimental research 22, 7 (1998): 1476-82. Details. Full text
  • Fillmore, MT ;Vogel-Sprott, M. "Resistance to cognitive impairment under alcohol: the role of environmental consequences." Experimental and clinical psychopharmacology 5, 3 (1997): 251-5. Details. Full text
  • Fillmore, MT ;Vogel-Sprott, M. "Social drinking history, behavioral tolerance and the expectation of alcohol." Psychopharmacology 127, 4 (1996): 359-64. Details. Full text
  • Fillmore, MT ;Vogel-Sprott, M. "Evidence that expectancies mediate behavioral impairment under alcohol." Journal of studies on alcohol 57, 6 (1996): 598-603. Details. Full text
  • Miller, MA ;Weafer, J.;Fillmore, MT "Gender differences in alcohol impairment of simulated driving performance and driving-related skills." Alcohol and alcoholism (Oxford, Oxfordshire) 44, 6 (1969): 586-93. Details. Full text
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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