7-OH-DPAT has d-amphetamine-like discriminative stimulus properties.

Title7-OH-DPAT has d-amphetamine-like discriminative stimulus properties.
Publication TypeJournal Article
Year of Publication1997
JournalPharmacology, biochemistry, and behavior
Volume58
Issue2
Pagination485-90
ISSN0091-3057
Abstract

Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreased as the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (+/-)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties with the amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution.

URLhttps://linkinghub.elsevier.com/retrieve/pii/S0091-3057(97)00288-8
Short TitlePharmacol Biochem Behav
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