Dopamine D(2)-like receptor binding in the brain of male Japanese quail (Coturnix japonica).

TitleDopamine D(2)-like receptor binding in the brain of male Japanese quail (Coturnix japonica).
Publication TypeJournal Article
Year of Publication2000
JournalNeuroscience letters
Volume296
Issue2-3
Pagination77-80
Date Published2000
ISSN0304-3940
Abstract

Japanese quail (Coturnix japonica) have been used extensively to study appetitive behaviors. However, little is known about the appetitive-relevant neurochemical systems in this species. The present investigation examined the distribution of D(2)-like dopamine receptors in the quail brain. [(3)H]Spiperone was incubated in brain tissue homogenates and non-specific binding was defined using (-)-sulpiride. Scatchard analysis of whole brain without cerebellum and forebrain alone indicated approximate K(d)'s of 0.08 and 0.04 nM, respectively. In addition, the preferential D(3) agonist (+/-)-2-dipropylamino-7-hydroxy-1,2,3, 4-tetrahydronaphthalene hydrobromide (7-OH-DPAT) did not displace [(3)H]spiperone binding in quail forebrain. Finally, regional analysis showed that the highest densities of D(2)-like receptors were located in the forebrain. Overall, these results indicate that there is some conservation of dopaminergic mechanisms between aves and mammals. Thus, Japanese quail may be useful for examining the neuropharmacological mechanisms of dopaminergic stimulant drugs that work via D(2)-like receptor activation.

URLhttps://linkinghub.elsevier.com/retrieve/pii/S0304394000016517
Short TitleNeurosci Lett
X
Enter your linkblue username.
Enter your linkblue password.
Secure Login

This login is SSL protected

Loading