Effect of bupropion on nicotine self-administration in rats.

TitleEffect of bupropion on nicotine self-administration in rats.
Publication TypeJournal Article
Year of Publication2003
JournalPsychopharmacology
Volume169
Issue1
Pagination1-9
ISSN0033-3158
Abstract

The mechanisms underlying the therapeutic efficacy of bupropion as a smoking cessation agent are unknown. Bupropion inhibits monoamine uptake as well as neuronal nicotinic receptor (nAChR) function. The present study compared effects of bupropion on nicotine self-administration to those of other stimulant drugs (methamphetamine and apomorphine) that lack nAChR activity in order to determine its mechanism of action. To determine the specificity of bupropion-induced changes in nicotine self-administration, the ability of bupropion to alter sucrose-maintained responding or amphetamine self-administration was determined.

URLhttps://dx.doi.org/10.1007/s00213-003-1450-x
DOI10.1007/s00213-003-1450-x
Short TitlePsychopharmacology (Berl)
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