Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.

TitleEffect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
Publication TypeJournal Article
Year of Publication2006
JournalPsychopharmacology
Volume184
Issue3-4
Pagination426-34
ISSN0033-3158
Abstract

Recent work has shown that the novel compound N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) may selectively block nicotinic acetylcholine receptors involved in regulating dopamine release. The current experiments examined the acute effect of bPiDDB on nicotine self-administration, sucrose-maintained responding, and nicotine-induced changes in acute and sensitized locomotor activity.

URLhttps://dx.doi.org/10.1007/s00213-005-0163-8
DOI10.1007/s00213-005-0163-8
Short TitlePsychopharmacology (Berl)
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