Effects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.

TitleEffects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.
Publication TypeJournal Article
Year of Publication2002
JournalPharmacology, biochemistry, and behavior
Volume73
Issue3
Pagination611-22
ISSN0091-3057
Abstract

In a series of experiments, the ability of selective mu- (beta-funaltrexamine, beta-FNA), delta- (naltrindole, nalt) and kappa- (nor-binaltorphimine, nor-BNI) opioid receptor antagonists to attenuate the unconditioned and conditioned hyperactive effects of morphine was examined. For comparison, the nonselective opioid receptor antagonist naloxone (nalx) was also examined. Locomotor activity served as the behavioral measure. Experiment 1 found that doses of 1 and 4, but not 16 mg/kg, of morphine effectively produced conditioned hyperactivity (CH). Experiments 2a-d found that beta-FNA, nalt, nor-BNI and nalx, respectively, attenuated unconditioned morphine-induced hyperactivity. Experiments 3a-c, however, found that none of the selective antagonists, given individually, attenuated CH. In contrast, nalx did attenuate CH (Experiment 3d). Collectively results suggest that the unconditioned and conditioned hyperactive responses to morphine are mediated by different receptor systems and that activation of multiple opioid-receptor subtypes mediate expression of CH.

URLhttps://linkinghub.elsevier.com/retrieve/pii/S0091305702008559
Short TitlePharmacol Biochem Behav
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