Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3.
| Title | Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Journal | Alcoholism, clinical and experimental research |
| Volume | 40 |
| Issue | 7 |
| Pagination | 1454-61 |
| ISSN | 0145-6008 |
| Abstract | Prior studies demonstrate that ethanol (EtOH) exposure induces the release of intracellular calcium (CA(2+) ) in modulation of γ-aminobutyric acid-ergic tone and produces concomitant alterations in sigma (σ)-1 protein expression that may contribute to the development EtOH dependence. However, the influence of CA(2+) released from endoplasmic reticulum (ER)-bound inositol triphosphate (IP3) and σ-1 receptors in regulating hippocampal function has yet to be delineated. |
| URL | https://doi.org/10.1111/acer.13097 |
| DOI | 10.1111/acer.13097 |
| Short Title | Alcohol Clin Exp Res |
