Individual differences in novelty seeking on the playground maze predict amphetamine conditioned place preference.

TitleIndividual differences in novelty seeking on the playground maze predict amphetamine conditioned place preference.
Publication TypeJournal Article
Year of Publication1999
JournalPharmacology, biochemistry, and behavior
Volume63
Issue1
Pagination131-6
ISSN0091-3057
Abstract

Previous research has shown that a rat's level of activity in a novel environment can predict the strength of amphetamine-induced locomotor behavior and self-administration, but not amphetamine-conditioned place preference. The increase in activity observed when a rat is exposed to an inescapable novel environment may reflect escape behavior due to stress. To assess approach to novelty in a free-choice test, we examined the ability of a new test, the playground maze, to predict individual differences in response to amphetamine (1 or 3 mg/kg). Using the playground maze to categorize rats as either high or low novelty seekers, it was found that individual differences in novelty seeking did not predict amphetamine-induced changes in locomotor activity following either a single or repeated injections. However, high novelty seekers showed greater amphetamine-conditioned place preference than low novelty seekers. These results provide support for the hypothesis that novelty seeking and drug reward are neuropharmacologically related.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0091-3057(98)00258-5
Short TitlePharmacol Biochem Behav
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