The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats.

TitleThe monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats.
Publication TypeJournal Article
Year of Publication2007
JournalBehavioural pharmacology
Volume18
Issue7
Pagination601-8
ISSN0955-8810
Abstract

In addition to delivering nicotine, tobacco smoke also inhibits monoamine oxidase (MAO). Although MAO inhibitors (MAOIs) can increase nicotine self-administration in rodents, the effects of MAOIs on the discriminative stimulus effect of nicotine are not known. This study examined the effects of three MAOIs (phenelzine, clorgyline and pargyline) with varying selectivity for MAOA and MAOB in the nicotine drug discrimination procedure in rats. Adult male Sprague-Dawley rats were trained to discriminate nicotine (0.3 mg/kg, subcutaneously) from saline in a standard, two-lever food-reinforced operant task. Once the discrimination was acquired, the ability of each MAOI to substitute for or alter the discriminative stimulus effect of nicotine was determined. In substitution tests, nicotine (0.03-0.3 mg/kg) produced full, dose-dependent substitution. Although the selective MAOA inhibitor clorgyline (3-56 mg/kg) and the selective MAOB inhibitor pargyline (3-56 mg/kg) did not elicit any nicotine-appropriate responding, partial substitution was obtained with the nonselective MAO inhibitor phenelzine (1-17 mg/kg). Phenelzine (10 mg/kg) also enhanced the discriminative stimulus effect of a low dose of nicotine (0.056 mg/kg) and prolonged the time course effect of the nicotine-training dose. These findings indicate that concomitant inhibition of MAOA and MAOB can enhance the discriminative stimulus effect of nicotine in rats.

URLhttp://Insights.ovid.com/pubmed?pmid=17912044
DOI10.1097/FBP.0b013e3282eff0d5
Short TitleBehav Pharmacol
X
Enter your linkblue username.
Enter your linkblue password.
Secure Login

This login is SSL protected

Loading