On the nature of the intra-administration unconditioned stimulus: comment on McDonald and Siegel (2004).

TitleOn the nature of the intra-administration unconditioned stimulus: comment on McDonald and Siegel (2004).
Publication TypeJournal Article
Year of Publication2004
JournalExperimental and clinical psychopharmacology
Volume12
Issue1
Pagination12-4; discussion 23-6
ISSN1064-1297
Abstract

R. V. McDonald and S. Siegel (see record 2004-10475-001) present convincing evidence that a small dose of morphine (5 mg/kg) may elicit withdrawal signs in rats previously injected on a number of occasions with a large dose of morphine (50 mg/kg), thus suggesting that intra-administration associations may be involved in drug withdrawal. This finding is important for basic and applied researchers studying drug reward mechanisms. Although R. V. McDonald and S. Siegel point out that the morphine conditional stimulus (CS) and unconditioned stimulus (US) making up the intra-administration association differ in onset and magnitude, the author of this comment argues that the CS and US may also differ in terms of pharmacologic activity.

URLhttp://content.apa.org/journals/pha/12/1/12
DOI10.1037/1064-1297.12.1.12
Short TitleExp Clin Psychopharmacol
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