Opioid mediation of cocaine-induced hyperactivity and reinforcement.

TitleOpioid mediation of cocaine-induced hyperactivity and reinforcement.
Publication TypeJournal Article
Year of Publication1989
JournalBrain research
Volume497
Issue1
Pagination195-8
Date Published1989
ISSN0006-8993
Abstract

The mechanisms by which cocaine produces hyperactivity and reinforcement remain poorly understood. Since reinforcement is also a property of other drugs of abuse including opiates, we examined the possible mediation of these cocaine-induced behaviors by endogenous opioid peptides. In this study, we have confirmed reports that cocaine increases locomotor activity and conditioned place preference in rats. We have also demonstrated that opioid receptor blockade with naloxone antagonizes completely the locomotor-activating effect of cocaine and attenuates the strength of the place preference conditioning produced by cocaine. These data support the thesis that endogenous opioids are involved in mediation of cocaine-induced behavior.

URLhttp://linkinghub.elsevier.com/retrieve/pii/0006-8993(89)90989-X
Short TitleBrain Res
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