Mark Prendergast

prender's picture
Graduate Training: 
Ph.D. Univ. of Nebraska, 1994
Research: 

My laboratory's research efforts are focused on examining mechanisms involved in the development of alcohol dependence and the biochemistry of brain injury resulting from exposure to:
  1.  alcohol
  2.  "stress hormones"
  3.  pesticides
  4.  psychomotor stimulants

In studying these topics, my laboratory employs a broad range of neurochemical and behavioral techniques, including cell culture of brain tissue, in vivo rodent studies, Western blot analysis and immunohistochemistry.

 

 

Selected Publications: 

     Butler TR, Smith KJ,  Self RL, Braden BB, Prendergast MA (2008). Sex differences in neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal in vitro: reversal with co-exposure to an A1 receptor agonist or and NMDA receptor antagonist. Alcoholism Clinical and Experimental Research, 32(7), 1260-1270.

     Self RL, Smith KJ, Butler TR, Pauly JR, Prendergast MA (2009). Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 transcription factor Tat exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial learning deficits. Neuroscience, 163, 868-876.

     Butler TR, Self RL, Smith KJ, Sharrett-Field LJ, Berry JN, Littleton JM, Pauly JR, Mulholland PJ, Prendergast MA (2010). Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. Neuroscience165(2):525-34.

     Butler TR and Prendergast MA (In Press). Neuroadaptations in adenosine receptor signaling following long-term ethanol exposure and withdrawal. Alcoholism: Clinical and Experimental Research

     Prendergast MAand Mulholland PJ (In Press) Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury. Addiction Biology

Pubmed Publications: 
  • Sharrett-Field, L.;Butler, T.R.;Reynolds, A.R.;Berry, J.N.;Prendergast, M.A. "Sex differences in neuroadaptation to alcohol and withdrawal neurotoxicity." Pflugers Archiv : European journal of physiology 465, 5 (2013): 643-54. Details. Full text
  • Sharrett-Field, L.;Butler, T.R.;Berry, J.N.;Reynolds, A.R.;Prendergast, M.A. "Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo." Alcoholism, clinical and experimental research (2013): Details. Full text
  • Rumbaugh, J.A.;Bachani, M.;Li, W.;Butler, T.R.;Smith, K.J.;Bianchet, M.A.;Wang, T.;Prendergast, M.A.;Sacktor, N.;Nath, A. "HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors." Neurobiology of disease 49C, (2012): 169-176. Details. Full text
  • Prendergast, M.A.;Mulholland, P.J. "Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury." Addiction biology 17, 2 (2012): 209-23. Details. Full text
  • Butler, T.R.;Prendergast, M.A. "Neuroadaptations in adenosine receptor signaling following long-term ethanol exposure and withdrawal." Alcoholism, clinical and experimental research 36, 1 (2012): 4-13. Details. Full text
  • Berry, J.N.;Sharrett-Field, L.J.;Butler, T.R.;Prendergast, M.A. "Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury." Neuroscience 222, (2012): 147-58. Details. Full text
  • Thompson, D.O.;Prendergast, M.A.;Shockley, L.W. "Traumatic pneumothorax with air mimicking lung markings." The Journal of emergency medicine 43, 6 (2012): e463-4. Details. Full text
  • Rahman, S.;Prendergast, M.A. "Cholinergic receptor system as a target for treating alcohol abuse and dependence." Recent patents on CNS drug discovery 7, 2 (2012): 145-50. Details. Full text
  • Butler, T.R.;Smith, K.J.;Self, R.L.;Braden, B.B.;Prendergast, M.A. "Neurodegenerative effects of recombinant HIV-1 Tat(1-86) are associated with inhibition of microtubule formation and oxidative stress-related reductions in microtubule-associated protein-2(a,b)." Neurochemical research 36, 5 (2011): 819-28. Details. Full text
  • Stairs, D.J.;Prendergast, M.A.;Bardo, M.T. "Environmental-induced differences in corticosterone and glucocorticoid receptor blockade of amphetamine self-administration in rats." Psychopharmacology 218, 1 (2011): 293-301. Details. Full text
  • Smith, K.J.;Butler, T.R.;Prendergast, M.A. "Inhibition of sigma-1 receptor reduces N-methyl-D-aspartate induced neuronal injury in methamphetamine-exposed and -naive hippocampi." Neuroscience letters 481, 3 (2010): 144-8. Details. Full text
  • Rose, A.K.;Shaw, S.G.;Prendergast, M.A.;Little, H.J. "The importance of glucocorticoids in alcohol dependence and neurotoxicity." Alcoholism, clinical and experimental research 34, 12 (2010): 2011-8. Details. Full text
  • Butler, T.R.;Self, R.L.;Smith, K.J.;Sharrett-Field, L.J.;Berry, J.N.;Littleton, J.M.;Pauly, J.R.;Mulholland, P.J.;Prendergast, M.A. "Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors." Neuroscience 165, 2 (2010): 525-34. Details. Full text
  • Self, R.L.;Smith, K.J.;Butler, T.R.;Pauly, J.R.;Prendergast, M.A. "Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting..." Neuroscience 163, 3 (2009): 868-76. Details. Full text
  • Jacquot, C.;Croft, A.P.;Prendergast, M.A.;Mulholland, P.;Shaw, S.G.;Little, H.J. "Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption." Alcoholism, clinical and experimental research 32, 12 (2008): 2107-16. Details. Full text
  • Barron, S.;Mulholland, P.J.;Littleton, J.M.;Prendergast, M.A. "Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures." Alcoholism, clinical and experimental research 32, 6 (2008): 929-36. Details. Full text
  • Smith, K.J.;Butler, T.R.;Self, R.L.;Braden, B.B.;Prendergast, M.A. "Potentiation of N-methyl-D-aspartate receptor-mediated neuronal injury during methamphetamine withdrawal in vitro requires co-activation of IP3 receptors." Brain research 1187, (2008): 67-73. Details. Full text
  • Butler, T.R.;Smith, K.J.;Self, R.L.;Braden, B.B.;Prendergast, M.A. "Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist." Alcoholism, clinical and experimental research 32, 7 (2008): 1260-70. Details. Full text
  • Buccafusco, J.J.;Powers, J.C.;Hernandez, M.A.;Prendergast, M.A.;Terry, A.V.;Jonnala, R.R. "MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition." Neurochemical research 32, 7 (2007): 1224-37. Details. Full text
  • Terry AV, J.;Gearhart, D.A.;Beck WD, J.;Truan, J.N.;Middlemore, M.L.;Williamson, L.N.;Bartlett, M.G.;Prendergast, M.A.;Sickles, D.W.;Buccafusco, J.J. "Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing." The Journal of pharmacology and experimental therapeutics 322, 3 (2007): 1117-28. Details. Full text
  • Gearhart, D.A.;Sickles, D.W.;Buccafusco, J.J.;Prendergast, M.A.;Terry AV, J. "Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility." Toxicology and applied pharmacology 218, 1 (2007): 20-9. Details. Full text
  • Prendergast, M.A.;Little, H.J. "Adolescence, glucocorticoids and alcohol." Pharmacology, biochemistry, and behavior 86, 2 (2007): 234-45. Details. Full text
  • Prendergast, M.A.;Self, R.L.;Smith, K.J.;Ghayoumi, L.;Mullins, M.M.;Butler, T.R.;Buccafusco, J.J.;Gearhart, D.A.;Terry AV, J. "Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity." Neuroscience 146, 1 (2007): 330-9. Details. Full text
  • Smith, K.J.;Self, R.L.;Butler, T.R.;Mullins, M.M.;Ghayoumi, L.;Holley, R.C.;Littleton, J.M.;Prendergast, M.A. "Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures." Brain research 1157, (2007): 74-80. Details. Full text
  • Wilkins LH, J.;Prendergast, M.A.;Blanchard, J.;Holley, R.C.;Chambers, E.R.;Littleton, J.M. "Potential value of changes in cell markers in organotypic hippocampal cultures associated with chronic EtOH exposure and withdrawal: comparison with NMDA-induced changes." Alcoholism, clinical and experimental research 30, 10 (2006): 1768-80. Details. Full text
  • Mulholland, P.J.;Self, R.L.;Hensley, A.K.;Little, H.J.;Littleton, J.M.;Prendergast, M.A. "A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis." Brain research 1082, 1 (2006): 165-72. Details. Full text
  • Mulholland, P.J.;Self, R.L.;Harris, B.R.;Little, H.J.;Littleton, J.M.;Prendergast, M.A. "Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures." Alcoholism, clinical and experimental research 29, 5 (2005): 871-81. Details. Full text
  • Self, R.L.;Smith, K.J.;Mulholland, P.J.;Prendergast, M.A. "Ethanol exposure and withdrawal sensitizes the rat hippocampal CA1 pyramidal cell region to beta-amyloid (25-35)-induced cytotoxicity: NMDA receptor involvement." Alcoholism, clinical and experimental research 29, 11 (2005): 2063-9. Details. Full text
  • Mulholland, P.J.;Self, R.L.;Harris, B.R.;Littleton, J.M.;Prendergast, M.A. "Choline exposure reduces potentiation of N-methyl-D-aspartate toxicity by corticosterone in the developing hippocampus." Brain research. Developmental brain research 153, 2 (2004): 203-11. Details. Full text
  • Self, R.L.;Mulholland, P.J.;Nath, A.;Harris, B.R.;Prendergast, M.A. "The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site." Brain research 995, 1 (2004): 39-45. Details. Full text
  • Self, R.L.;Mulholland, P.J.;Harris, B.R.;Nath, A.;Prendergast, M.A. "Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment." Alcoholism, clinical and experimental research 28, 12 (2004): 1916-24. Details. Full text
  • Mulholland, P.J.;Prendergast, M.A. "Transection of intrinsic polysynaptic pathways reduces N-methyl-D-aspartate neurotoxicity in hippocampal slice cultures." Neuroscience research 46, 3 (2003): 369-76. Details. Full text
  • Harris, B.R.;Gibson, D.A.;Prendergast, M.A.;Blanchard, J.A.;Holley, R.C.;Hart, S.R.;Scotland, R.L.;Foster, T.C.;Pedigo, N.W.;Littleton, J.M. "The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors." Alcoholism, clinical and experimental research 27, 11 (2003): 1724-35. Details. Full text
  • Terry AV, J.;Stone, J.D.;Buccafusco, J.J.;Sickles, D.W.;Sood, A.;Prendergast, M.A. "Repeated exposures to subthreshold doses of chlorpyrifos in rats: hippocampal damage, impaired axonal transport, and deficits in spatial learning." The Journal of pharmacology and experimental therapeutics 305, 1 (2003): 375-84. Details. Full text
  • Gibson, D.A.;Harris, B.R.;Prendergast, M.A.;Hart, S.R.;Blanchard JA, 2nd;Holley, R.C.;Pedigo, N.W.;Littleton, J.M. "Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor." Alcoholism, clinical and experimental research 27, 7 (2003): 1099-106. Details. Full text
  • Bain, J.N.;Prendergast, M.A.;Terry AV, J.;Arneric, S.P.;Smith, M.A.;Buccafusco, J.J. "Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential." Psychopharmacology 169, 2 (2003): 150-60. Details. Full text
  • Kelly, T.H.;Stoops, W.W.;Perry, A.S.;Prendergast, M.A.;Rush, C.R. "Clinical neuropharmacology of drugs of abuse: a comparison of drug-discrimination and subject-report measures." Behavioral and cognitive neuroscience reviews 2, 4 (2003): 227-60. Details. Full text
  • Mulholland, P.J.;Prendergast, M.A. "Post-insult exposure to (+/-) kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus." Brain research 945, 1 (2002): 106-13. Details. Full text
  • Prendergast, M.A.;Rogers, D.T.;Mulholland, P.J.;Littleton, J.M.;Wilkins LH, J.;Self, R.L.;Nath, A. "Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor." Brain research 954, 2 (2002): 300-7. Details. Full text
  • Prendergast, M.A.;Yells, D.P.;Balogh, S.E.;Paige, S.R.;Hendricks, S.E. "Fluoxetine differentially suppresses sucrose solution consumption in free-fed and food-deprived rats--reversal by amantadine." Medical science monitor : international medical journal of experimental and clinical research 8, 10 (2002): BR385-90. Details. Full text
  • Harris, B.R.;Prendergast, M.A.;Gibson, D.A.;Rogers, D.T.;Blanchard, J.A.;Holley, R.C.;Fu, M.C.;Hart, S.R.;Pedigo, N.W.;Littleton, J.M. "Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors." Alcoholism, clinical and experimental research 26, 12 (2002): 1779-93. Details. Full text
  • Mayer, S.;Harris, B.;Gibson, D.A.;Blanchard, J.;Prendergast, M.A.;Holley, R.C.;Littleton, J. "Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat." Alcoholism, clinical and experimental research 26, 5 (2002): 655-62. Details. Full text
  • Mayer, S.;Harris, B.R.;Gibson, D.A.;Blanchard, J.A.;Prendergast, M.A.;Holley, R.C.;Littleton, J. "Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus." Alcoholism, clinical and experimental research 26, 10 (2002): 1468-78. Details. Full text
  • Prendergast, M.A.;Rogers, D.T.;Barron, S.;Bardo, M.T.;Littleton, J.M. "Ethanol and nicotine: a pharmacologic balancing act?" Alcoholism, clinical and experimental research 26, 12 (2002): 1917-8. Details. Full text
  • Stone, J.D.;Terry AV, J.;Pauly, J.R.;Prendergast, M.A.;Buccafusco, J.J. "Protractive effects of chronic treatment with an acutely sub-toxic regimen of diisopropylflurophosphate on the expression of cholinergic receptor densities in rats." Brain research 882, 1-2 (2000): 9-18. Details. Full text
  • Prendergast, M.A.;Harris, B.R.;Blanchard JA, 2nd;Mayer, S.;Gibson, D.A.;Littleton, J.M. "In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat." Alcoholism, clinical and experimental research 24, 12 (2000): 1855-61. Details. Full text
  • Prendergast, M.A.;Harris, B.R.;Mayer, S.;Littleton, J.M. "Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro." Alcoholism, clinical and experimental research 24, 10 (2000): 1583-92. Details. Full text
  • Prendergast, M.A.;Buccafusco, J.J. "(-)-Nicotine increases mRNA encoding G3PDH and the vesicular acetylcholine transporter in vivo." Neuroreport 9, 7 (1998): 1385-9. Details. Full text
  • Terry AV, J.;Buccafusco, J.J.;Jackson, W.J.;Prendergast, M.A.;Fontana, D.J.;Wong, E.H.;Bonhaus, D.W.;Weller, P.;Eglen, R.M. "Enhanced delayed matching performance in younger and older macaques administered the 5-HT4 receptor agonist, RS 17017." Psychopharmacology 135, 4 (1998): 407-15. Details. Full text
  • Prendergast, M.A.;Jackson, W.J.;Terry AV, J.;Kille, N.J.;Arneric, S.P.;Decker, M.W.;Buccafusco, J.J. "Age-related differences in distractibility and response to methylphenidate in monkeys." Cerebral cortex (New York, N.Y. : 1991) 8, 2 (1998): 164-72. Details. Full text
  • Prendergast, M.A.;Jackson, W.J.;Terry AV, J.;Decker, M.W.;Arneric, S.P.;Buccafusco, J.J. "Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys." Psychopharmacology 136, 1 (1998): 50-8. Details. Full text
  • Prendergast, M.A.;Terry AV, J.;Jackson, W.J.;Marsh, K.C.;Decker, M.W.;Arneric, S.P.;Buccafusco, J.J. "Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418." Psychopharmacology 130, 3 (1997): 276-84. Details. Full text
  • Decker, M.W.;Bannon, A.W.;Curzon, P.;Gunther, K.L.;Brioni, J.D.;Holladay, M.W.;Lin, N.H.;Li, Y.;Daanen, J.F.;Buccafusco, J.J.;Prendergast, M.A.;Jackson, W.J.;Arneric, S.P. "ABT-089 2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride : II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys." The Journal of pharmacology and experimental therapeutics 283, 1 (1997): 247-58. Details. Full text
  • Prendergast, M.A.;Terry AV, J.;Buccafusco, J.J. "Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning." Psychopharmacology 129, 2 (1997): 183-91. Details. Full text
  • Lin, N.H.;Gunn, D.E.;Ryther, K.B.;Garvey, D.S.;Donnelly-Roberts, D.L.;Decker, M.W.;Brioni, J.D.;Buckley, M.J.;Rodrigues, A.D.;Marsh, K.G.;Anderson, D.J.;Buccafusco, J.J.;Prendergast, M.A.;Sullivan, J.P.;Williams, M.;Arneric, S.P.;Holladay, M.W. "Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties." Journal of medicinal chemistry 40, 3 (1997): 385-90. Details. Full text
  • Prendergast, M.A.;Terry AV, J.;Jackson, W.J.;Buccafusco, J.J. "Nitric oxide synthase inhibition impairs delayed recall in mature monkeys." Pharmacology, biochemistry, and behavior 56, 1 (1997): 81-7. Details. Full text
  • Prendergast, M.A.;Hendricks, S.E.;Yells, D.P.;Balogh, S. "Conditioned taste aversion induced by fluoxetine." Physiology & behavior 60, 1 (1996): 311-5. Details. Full text
  • Terry AV, J.;Buccafusco, J.J.;Prendergast, M.A.;Jackson, W.J.;Fontana, D.L.;Wong, E.H.;Whiting, R.L.;Eglen, R.M. "The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys." Neuroreport 8, 1 (1996): 49-54. Details. Full text
  • Yells, D.P.;Prendergast, M.A.;Hendricks, S.E.;Miller, M.E. "Monoaminergic influences on temporal patterning of sexual behavior in male rats." Physiology & behavior 58, 5 (1995): 847-52. Details. Full text
  • Yells, D.P.;Prendergast, M.A.;Hendricks, S.E.;Nakamura, M. "Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis." Pharmacology, biochemistry, and behavior 49, 1 (1994): 121-7. Details. Full text
  • Yells, D.P.;Hendricks, S.E.;Prendergast, M.A. "Lesions of the nucleus paragigantocellularis: effects on mating behavior in male rats." Brain research 596, 1-2 (1992): 73-9. Details. Full text
  • Hart, R.A.;Prendergast, M.A.;Roberts, W.G.;Nesbit, G.M.;Barnwell, S.L. "Proximal junctional acute collapse cranial to multi-level lumbar fusion: a cost analysis of prophylactic vertebral augmentation." The spine journal : official journal of the North American Spine Society 8, 6 (1969): 875-81. Details. Full text
  • Prendergast, M.A. "Do women possess a unique susceptibility to the neurotoxic effects of alcohol?" Journal of the American Medical Women's Association (1972) 59, 3 (1969): 225-7. Details.
  • Butler, T.R.;Smith, K.J.;Berry, J.N.;Sharrett-Field, L.J.;Prendergast, M.A. "Sex differences in caffeine neurotoxicity following chronic ethanol exposure and withdrawal." Alcohol and alcoholism (Oxford, Oxfordshire) 44, 6 (1969): 567-74. Details. Full text
  • Prendergast, M.A.;Harris, B.R.;Mayer, S.;Holley, R.C.;Pauly, J.R.;Littleton, J.M. "Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit." Medical science monitor : international medical journal of experimental and clinical research 7, 6 (1969): 1153-60. Details.
  • Briggs, C.A.;Anderson, D.J.;Brioni, J.D.;Buccafusco, J.J.;Buckley, M.J.;Campbell, J.E.;Decker, M.W.;Donnelly-Roberts, D.;Elliott, R.L.;Gopalakrishnan, M.;Holladay, M.W.;Hui, Y.H.;Jackson, W.J.;Kim, D.J.;Marsh, K.C.;O'Neill, A.;Prendergast, M.A.;Ryther, K.B.;Sullivan, J.P.;Arneric, S.P. "Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo." Pharmacology, biochemistry, and behavior 57, 1-2 (1969): 231-41. Details. Full text
  • Clarke, M.S.;Prendergast, M.A.;Terry AV, J. "Plasma membrane ordering agent pluronic F-68 (PF-68) reduces neurotransmitter uptake and release and produces learning and memory deficits in rats." Learning & memory (Cold Spring Harbor, N.Y.) 6, 6 (1969): 634-49. Details. Full text
  • Prendergast, M.A.;Terry AV, J.;Buccafusco, J.J. "Effects of chronic, low-level organophosphate exposure on delayed recall, discrimination, and spatial learning in monkeys and rats." Neurotoxicology and teratology 20, 2 (1969): 115-22. Details. Full text
  • Prendergast, M.A.;Buccafusco, J.J.;Terry AV, J. "Nitric oxide synthase inhibition impairs spatial navigation learning and induces conditioned taste aversion." Pharmacology, biochemistry, and behavior 57, 1-2 (1969): 347-52. Details. Full text
  • Mulholland, P.J.;Harris, B.R.;Wilkins, L.H.;Self, R.L.;Blanchard, J.A.;Holley, R.C.;Littleton, J.M.;Prendergast, M.A. "Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression." Alcohol (Fayetteville, N.Y.) 31, 1-2 (1969): 1-10. Details. Full text
  • Devaud, L.L.;Prendergast, M.A. "Introduction to the special issue of Alcohol and Alcoholism on sex/gender differences in responses to alcohol." Alcohol and alcoholism (Oxford, Oxfordshire) 44, 6 (1969): 533-4. Details. Full text
  • Prendergast, M.A.;Harris, B.R.;Mullholland, P.J.;Blanchard JA, 2nd;Gibson, D.A.;Holley, R.C.;Littleton, J.M. "Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors." Neuroscience 124, 4 (0): 869-77. Details. Full text
  • Mulholland, P.J.;Self, R.L.;Stepanyan, T.D.;Little, H.J.;Littleton, J.M.;Prendergast, M.A. "Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro." Neuroscience 135, 4 (0): 1129-39. Details. Full text
  • Hart, R.A.;Prendergast, M.A. "Spine surgery for lumbar degenerative disease in elderly and osteoporotic patients." Instructional course lectures 56, (0): 257-72. Details.
  • Mulholland, P.J.;Self, R.L.;Harris, B.R.;Littleton, J.M.;Prendergast, M.A. "(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity." Neuroscience 125, 3 (0): 671-82. Details. Full text
  • Mulholland, P.J.;Stepanyan, T.D.;Self, R.L.;Hensley, A.K.;Harris, B.R.;Kowalski, A.;Littleton, J.M.;Prendergast, M.A. "Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures." Neuroscience 136, 1 (0): 259-67. Details. Full text
  • Prendergast, M.A.;Harris, B.R.;Mayer, S.;Holley, R.C.;Hauser, K.F.;Littleton, J.M. "Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression." Neuroscience 102, 1 (0): 75-85. Details. Full text
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